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Specs are compiled from manufacturer listings and verified buyer reviews and can change over time — please confirm the key details on the product page before buying.
Trimethylglycine — usually shortened to TMG, and also sold as betaine anhydrous or glycine betaine — is a supplement people buy for one of three reasons: to support a normal homocysteine level, to keep methylation (a basic housekeeping process your cells run every day) ticking along, or to see whether it sharpens daily energy. The catch is that most bottles look nearly identical on the shelf: same white capsules, same promises, wildly different serving sizes and capsule counts. The five picks below fix that. Each one earns its spot for a specific reason — the lowest cost per capsule, the highest single serving strength, the largest count in one bottle, or the purest one-ingredient formula — so you can pick by what actually matters to you instead of by label design.
This guide is built by comparing the manufacturers’ published specifications and the patterns across verified customer reviews, so you get each pick’s real strengths and trade-offs instead of marketing spin.
You will see exactly how many milligrams sit in each capsule, how many capsules come in a bottle, and how long that bottle actually lasts at the stated dose. By the end you will know which trimethylglycine supplement fits your routine, your capsule comfort, and your budget.
Top Picks
How To Choose The Best Trimethylglycine Supplement
Three numbers decide almost everything about a TMG bottle: how many milligrams are in one serving, how many capsules that serving takes, and how many capsules the bottle holds. Get those three right and you will not care what the front of the label says.
Read the serving size, not the headline number
A bottle that advertises 1,000 mg might deliver that in a single tablet or spread it across two capsules — and a bottle labeled 500 mg may reach the same total with two capsules. The milligram figure only means something next to the serving size. Check both lines before comparing anything, because a formula requiring two capsules per dose drains the bottle twice as fast as a single-capsule dose at the same strength.
Count capsules, then count days
Capsule count is where the real differences live. A 60-capsule bottle at two capsules a day gives you a 30-day supply, while a 180-capsule bottle at the same dose stretches considerably longer. Neither is automatically better — the big bottle simply means fewer reorders. If you travel or prefer a small bottle in the bag, the lower count is a feature, not a flaw.
Capsules or tablets, and what sits alongside the TMG
TMG comes in both soft capsules and compressed tablets. Capsules slip down easily and are the more common format; tablets are denser and often sold in larger counts, though a tablet can carry slightly sharp edges. The other decision is the ingredient list. Some formulas are deliberately stripped to a single ingredient with no additives, stearates, or rice fillers, while others are built into a broader blend. If you are stacking TMG with other supplements or medications, show the label to a healthcare professional first — the fillers matter less than what the total daily dose looks like across everything you take.
Side-by-Side Comparison
| Model | Best For | Strength Per Serving | Capsules Per Bottle | Format | Amazon |
|---|---|---|---|---|---|
| 10X Health TMG Supplements★ Best Overall | Daily energy support | 1,000 mg | 60 | Capsules | Amazon |
| NutriONN TMG Trimethylglycine 1000mgPremium Pick | Long-lasting bottle value | 1,000 mg | 180 | Capsules | Amazon |
| Swanson TMG Trimethylglycine 500 mg | Lower dose per capsule | 500 mg | 90 (2 Pack) | Capsules | Amazon |
| Pure Original Ingredients TMG Betaine | Single-ingredient purity | — | 365 | Capsules | Amazon |
| Vitamatic TMG 1000mg | Multi-bottle stock-up | 1,000 mg | 120 (3 Bottles) | Tablets | Amazon |
Detailed Reviews
1. 10X Health TMG Supplements 60 Capsules
Our pick — 4.5+★ from 600+ verified ratings; the strongest balance of quality and price.
The one people stick with — a full 1,000 mg dose in two capsules, no measuring, no mixing.
If you have ever tried a TMG powder, you already know the annoyance: scoop, stir, taste something faintly bitter, repeat. This bottle exists to delete that step. Each two-capsule serving hands you 1,000 mg of trimethylglycine in the betaine anhydrous form — the same compound sold as glycine betaine — and the whole routine is swallow two capsules with food. That is the entire protocol. At 60 capsules per bottle you are holding a stated 30 servings, which the maker frames as a 30-day supply taken as directed.
Where this one separates itself from the cheaper bottles on this list is the sheer compactness of the packaging. Its box is 3.43 x 1.81 x 1.73 inches and the whole thing weighs 2.4 ounces, so it disappears into a toiletry bag or a desk drawer. The Vitamatic bottle, by contrast, ships at 8.62 x 5.31 x 2.8 inches — this one is built for the gym bag, not the pantry shelf. On raw capsule count it is the smallest bottle here, well behind the 365-capsule Pure Original Ingredients jar, and that is the honest trade: you buy convenience and a clean daily dose, not volume.
Buyers most often describe feeling more active through the day, and the label sticks to methylation and homocysteine rather than padding the formula with extras. Capsules go down easily, and several buyers specifically note zero stomach upset, which is the detail that keeps a daily supplement in the rotation. The one thing that splits opinion is what you are paying for that convenience — some call it excellent value, others feel the smaller 60-capsule count makes it pricey to keep restocking. That is a real consideration, not a knock on the formula itself.
What keeps it in the daily rotation
- 1,000 mg of TMG per two-capsule serving — no scoop, no mixing, no taste
- Compact 3.43 x 1.81 x 1.73 inch bottle at 2.4 ounces, so it travels easily
- Two capsules with food once daily covers a stated 30-day supply
- Ease of swallowing and a calm stomach are the standout notes from long-term users
Where you feel the trade-off
- 60 capsules is the smallest count on this list, so the bottle empties fastest
- Whether the convenience is worth it splits opinion — some see value, others see a premium for the same molecule
- Improvement is not instant for everyone; the pattern is a couple of weeks before you notice a difference
The pick for you: anyone who wants a precise 1,000 mg dose with the least possible fuss and a bottle that fits a small bag.
Reconsider: if you would rather buy once and forget it for months, the 180-capsule NutriONN or the 365-capsule Pure Original Ingredients bottle stretches further.
2. TMG Trimethylglycine 180 Capsules
A 1,000 mg dose that does not ask you to reorder every month — 180 capsules of non-GMO betaine anhydrous.
The math here is the whole pitch. NutriONN puts 1,000 mg of trimethylglycine into a two-capsule serving, exactly like the 10X Health bottle, but ships 180 capsules instead of 60. That is three times the capsule count at the same strength, which means far fewer reorders across a year. For anyone who has settled on a TMG dose and simply wants to stop thinking about it, this is the bottle that disappears into a cabinet and stays there.
The formula is GMO-free, and the maker emphasizes TMG’s two jobs: supporting normal homocysteine levels and acting as a methyl donor in methylation pathways. The label also lists cardiovascular support and normal blood pressure. Worth being clear about what that means in practice — the recurring buyer theme is energy and focus rather than any dramatic overnight change. Capsules are described as smooth and easy to take, and the dose is generous. If your aim is a 1,000 mg daily anchor without a monthly reorder, this one quietly wins on capsule count.
Best suited to: the set-and-forget buyer who wants 1,000 mg daily and a bottle that runs for months, not weeks.
Worth knowing: the format is a larger 4.8 x 2.48 x 2.48 inch bottle weighing 4.97 ounces — fine in a cabinet, less ideal for a small travel kit.
If you want volume without the reorder: this is the 1,000 mg bottle that keeps going, and the non-GMO formula is a straight match for daily use.
If you are supplement-sensitive: ease in rather than jumping straight to the full two-capsule dose.
3. Swanson TMG Trimethylglycine 500 mg 2 Pack
Half the strength per capsule, two bottles in the box — the flexible option for a gentler starting dose.
Every other bottle here delivers 1,000 mg per serving. Swanson splits the difference: 500 mg per capsule, 90 capsules per bottle, and two bottles in the pack. Taking two capsules once a day as directed lands you at a 1,000 mg total anyway — the difference is that you can take one capsule and stop there when you want to.
Swanson’s formula targets cardiovascular support and liver function in an easy-to-swallow capsule. The formula is also non-GMO and the maker states it is produced in GMP certified facilities, which is a manufacturing-standard claim — meaning the facility meets a recognized quality framework — with purity and potency testing that includes independent third-party labs. For buyers who read the back of the label before the front, that is the substance here.
The strength-per-serving gap is also the clearest difference versus the Vitamatic bottle, which delivers 1,000 mg per serving — this one asks you to take two capsules to reach that same total. Feedback follows two honest threads. On the plus side, the recurring theme is that it does its job and the price-to-value relationship is genuinely good for this category. The recurring gripe is side effects, with headaches being the one called out; the on-again, off-again variability is a sensible reason to introduce it slowly. A separate practical note worth acting on: like all supplements, check the expiry date on arrival, because bulk packs can land with shorter windows than you would hope.
The angle on this bottle: buy it when flexibility matters more than milligrams — one capsule or two, your call, across two separate bottles.
Where it lands: at 2.3 x 4.6 x 4.4 inches and 7.2 ounces, it is the heaviest package here, since you are getting two bottles rather than one.
Pick it if: you want a 500 mg capsule you can titrate, backed by a brand with a long history in this space.
Better elsewhere: if 1,000 mg in a single serving and a smaller bottle are what you are after, the 10X Health or NutriONN pick suits you better.
4. Pure Original Ingredients Tmg Betaine 365 Capsules
One ingredient, nothing else in the capsule — and 365 of them in a single jar.
Some people want a blend. Some want the shortest possible ingredient list, full stop. This is that bottle. The capsules are filled with a single ingredient, TMG, described as pure and undiluted, with no additives, stearates, or rice fillers tucked in alongside it. If your kitchen counter already looks like a pharmacy and you want the most stripped-down version of this molecule you can buy, the label here is about as plain as it gets.
The count is the other headline. At 365 capsules this is — by a wide margin — the largest single jar on the list, and the physical bottle reflects it: 5.51 x 2.99 x 2.8 inches at 9.88 ounces. Compare that with the smaller 10X Health bottle at 3.43 x 1.81 x 1.73 inches and 2.4 ounces and you can see the trade immediately: this one is a pantry jar that you fill from, not a pocket companion. Stack it against the 60-capsule option and the point is even plainer — you are buying in bulk, and the jar is sized accordingly.
One honest gap to flag: the listing does not publish a stated milligram strength per serving or a stated servings-per-bottle figure, so if hitting an exact milligram target is your priority, this is the one pick where you would want to confirm the details on the product page before committing. What you can count on is the format and the purity angle. If your decision is driven by “single ingredient, no fillers, big jar, done,” this is the fit — and readers who care most about purity over exact dosing tend to land here.
For the minimalist: you want one ingredient, no fillers, and a jar that lasts a long time — this is the cleanest label on the list.
Look elsewhere if: you need a published per-serving milligram figure to match a specific daily target, in which case the 1,000 mg picks above are the safer call.
5. Vitamatic TMG Supplements 1000mg 3 Bottles
Three bottles, 120 servings each, and a 1,000 mg tablet dose you take twice a day.
This is the stock-up box. Vitamatic ships three bottles, each holding 120 tablets at 1,000 mg of trimethylglycine per serving in the betaine anhydrous form. The serving structure is what matters here: 120 servings per bottle, taken as part of a twice-daily routine alongside your other supplements. If you like to buy once and not think about it again for a long stretch, the multi-bottle format is the entire reason this pick exists — and at 8.62 x 5.31 x 2.8 inches, the box is sized to be stored, not carried.
The formulation is clean on paper. It is premium grade, non-GMO and gluten free, and free of starch, yeast, corn, wheat, egg, artificial color, flavor and preservatives — a wide exclusion list for anyone who reacts to trace ingredients. It is made in a GMP compliant, FDA registered facility, and the stated focus is healthy homocysteine and cardiovascular support. The tablets are the other difference: unlike the capsules on the rest of this list, these are compressed, and the feedback is mixed on exactly that point — some find them fine, others find them noticeably large.
The practical notes are worth reading before you buy. These run large, and one detail that comes up is slightly sharp edges on some tablets — nothing that stops people taking them, but pairing with a full glass of water is sensible. They are also described as having no bad smell or taste, which makes the twice-daily routine easier to keep up. On effectiveness, owners mention tracking their own numbers and liking the results, including improved blood pressure readings. That is buyer-reported experience, not a medical outcome — pair TMG with professional guidance if you are monitoring anything clinical, especially if you take prescription medication.
The stockpile case: three bottles at 120 servings each, 1,000 mg per serving, gluten free and built for someone who plans in quarters rather than weeks.
The catch to size up: large tablets with occasional sharp edges — the format, not the formula, is what divides people here.
Reach for this if: you want the biggest single-purchase supply of 1,000 mg TMG and do not mind swallowing larger tablets twice a day.
Think twice if: you struggle with big pills — the capsule options above go down easier.
Know the Specs
Milligrams Per Serving vs Per Capsule
The headline milligram figure usually describes a full serving, which is often two capsules — not one. A bottle labeled 1,000 mg might mean two capsules, so check the serving line before you assume a single pill gives you the full dose. If you want to take just one capsule and stop, a 500 mg format is the one that lets you do that.
Betaine Anhydrous and Methyl Donors
Trimethylglycine is sold under several names: TMG, betaine anhydrous, and glycine betaine all describe the same compound. A methyl donor is a molecule that hands off a methyl group — a small chemical unit — to help your body complete methylation, a routine housekeeping process involved in homocysteine metabolism. That is why so many TMG labels talk about homocysteine and methylation together.
Supply Length and Capsule Count
Divide the capsule count by the capsules per serving and you get the number of days the bottle lasts. A 60-capsule bottle at two capsules a day is a stated 30-day supply; a 180-capsule bottle at the same dose runs three times longer. This is the number that tells you how often you will reorder — and the number most buyers forget to check.
Expiry Dates on Bulk Packs
Buying in bulk only saves time if the shelf life stretches far enough. Bulk multi-packs and large jars can arrive with shorter expiry windows than expected, so glance at the date on arrival. Stored properly per the label, most supplements in this category are formulated for a set period from the manufacture date — check the bottle for the exact date.
Common Questions
What is the difference between TMG, betaine anhydrous, and glycine betaine?
How many capsules of TMG should I take per day?
Is a 1,000 mg TMG supplement stronger than a 500 mg one?
How long does a bottle of TMG capsules last?
Can I take TMG at the same time as other supplements or medication?
Do TMG capsules or tablets work better?
Why do some TMG formulas say non-GMO and gluten free?
How should I store a bulk pack of TMG capsules?
Does TMG need to be taken with food?
Why is the single-ingredient TMG bottle priced similarly to larger multi-capsule options?
The Bottom Line
For most people, the trimethylglycine supplement to start with is the 10X Health TMG Supplement, because it hands you a full 1,000 mg dose in two capsules with no measuring, no mixing, and a bottle small enough to take anywhere. If you would rather buy once and reorder rarely, the NutriONN TMG 1000mg gives you the same 1,000 mg serving across 180 capsules, and the Pure Original Ingredients TMG Betaine goes furthest of all with a single-ingredient formula and 365 capsules in one jar. For a lower per-capsule dose you can titrate yourself, the Swanson TMG 500 mg 2 Pack is the flexible choice; for a three-bottle supply of 1,000 mg tablets, the Vitamatic TMG 1000mg is built to be stored. Any of the five will do the same core job — pick by capsule count and the milligram target you actually want to hit each day.
How we choose
We do not accept paid placement. Every pick is matched to a real buyer and a real use-case; we do not hands-on test units.
Sources
Specifications: manufacturer listings and product documentation. Review insights: verified customer reviews, as of October 2026. Pricing: not shown on this page (it changes often); check the current price via the retailer link.
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